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CBD and Depression

Depression is a mood disorder that is known for its symptoms of persistent sadness, a loss of interest in life, pessimism that can lead to decreased appetite and energy, and suicidal thoughts. Much like the internal mechanisms described in Anxiety, CBD can help treat depression through its influence on the 5-HT1A serotonin receptors. CBD acts to naturally increase the amount of serotonin available to the body, just like the common serotonin reuptake inhibitors (SSRIs) that are often prescribed for depression. In 2008, researchers concluded that the endocannabinoid system could provide a novel new way to treat depression,1 while a 2016 study supported CBD as a fast-acting anti-depressant drug.2

  1. Matthew N. Hill et al., “Regional Alterations in the Endocannabinoid System in an Animal Model of Depression: Effects of Concurrent Antidepressant Treatment,” Journal of Neurochemistry 106, no. 6 (2008): 2322–36, doi:10.1111/j.1471-4159.2008.05567.x.
  2. Raquel Linge et al., “Cannabidiol Induces Rapid-Acting Antidepressant-like Effects and Enhances Cortical 5-HT/Glutamate Neurotransmission: Role of 5-HT1A Receptors,” Neuropharmacology 103, (December 2015): 16–26, doi:10.1016/j. neuropharm.2015.12.017.